Pragmatic clinical trials to optimise treatments for patients with refractory cancers

IMPORTANT  |   IMPlementing geriatric assessment for dose Optimization of CDK 4/6-inhibitors in older bReasT cAncer patieNTs

CARE 1  | First line randomized study platform to optimize treatment in patients with metastatic renal cell carcinoma

IntReALL 2020  |  International Study for Treatment of Childhood Relapsed ALL 2020

LIVERATION  |   Unravelling the impact of Radiofrequency in liver surgery: the key to decrease local recurrence?

STREXIT 2  |  A pragmatic clinical study of neoadjuvant chemotherapy followed by surgery versus surgery alone for patients with high risk  retroperitoneal sarcoma

PREGMATIL  |  Pragmatic approach to Adoptive Cell Therapy (ACT) using Tumor Infiltrating Lymphocytes (TIL) in selected solid tumors

SAGITTARIUS  |  A precision medicine trial leveraging blood-based tumor genomics to optimize treatment in operable stage III and high risk stage II colon cancer patients  - the  SAGITTARIUS trial

LEGATO  |  Lomustine with or without reirradiation for first progression of glioblastoma: a pragmatic randomized phase III study

SALVOVAR  | A European multi-disciplinary clinical project meant to improve  the management of patients with poor prognostic ovarian cancer  after neoadjuvant chemotherapy: restoring hope, salvaging lives

DE-ESCALATE  |  Intermittent androgen deprivation therapy in the era of androgen receptor pathway inhibitors; a phase 3 pragmatic randomised trial

IMPACT-AML |  Master Framework and Pragmatic Clinical Trial for Relapse or Refractory Acute Myeloid Leukemia

PRIME-ROSE |  PRecisIon Cancer MEdicine RepurpOsing SystEm Using Pragmatic Clinical Trials